Accelerated approval for PRAXBIND was granted based on results from Phase I data in healthy volunteers. PRAXBIND is the first and only specific non-vitamin K antagonist oral anticoagulant (NOAC) reversal agent approved for use in emergency situations when immediate reversal of the anticoagulant effect of PRADAXA is required. The data captured via the RE-VECTO program will help the company better understand the actual usage of PRAXBIND in the clinical practice setting. The emergency situations in which PRAXBIND may be used can vary greatly, such as a car accident requiring emergency surgery or other severe bleeding events. Continued approval for this indication may be contingent upon the results of an ongoing cohort case series study. It is intended for patients treated with PRADAXA when reversal of the anticoagulant effects is needed for emergency surgery or other urgent life-threatening situations, such as a patient with uncontrolled bleeding.Īccording to a company representative, this indication received accelerated approval based on a reduction in unbound dabigatran and normalization of coagulation parameters in healthy volunteers. PRAXBIND is a reversal agent for PRADAXA. The program, titled RE-VECTO, will gather data to better understand the actual usage of PRAXBIND in clinical settings. By Ed Miseta, Chief Editor, Clinical Leaderįollow Me On Twitter Ingelheim Pharmaceuticals has announced the launch of a global program designed to evaluate the use of its PRAXBIND medicine, which received FDA approval in October 2015.
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Richard Garriott distributed the Applesoft BASIC written game originally as source code. Games with source code available on release Title In some cases when a game's source code is not available by other means, the game's community "reconstructs" source code from compiled binary files through time-demanding reverse engineering techniques. The game may be written in an interpreted language such as BASIC or Python, and distributed as raw source code without being compiled early software was often distributed in text form, as in the book BASIC Computer Games. SourceForge or GitHub), or given to selected game community members, or sold with the game, or become available by other means. The source code may be pushed by the developers to public repositories (e.g. Such source code is often released under varying (free and non-free, commercial and non-commercial) software licenses to the games' communities or the public artwork and data are often released under a different license than the source code, as the copyright situation is different or more complicated. In several of the cases listed here, the game's developers released the source code expressly to prevent their work from becoming abandonware. The source code of these commercially developed and distributed video games is available to the public or the games' communities. This is a list of commercial video games with available source code. ( August 2022) ( Learn how and when to remove this template message) Several templates and tools are available to assist in formatting, such as Reflinks ( documentation), reFill ( documentation) and Citation bot ( documentation). Please consider converting them to full citations to ensure the article remains verifiable and maintains a consistent citation style. This article uses bare URLs, which are uninformative and vulnerable to link rot. |